Tags: Cancer | breast | cancer | triple | negative | slow | metatastic

Common Drug May Slow Deadly Breast Cancer

Common Drug May Slow Deadly Breast Cancer
(Copyright DPC)

By    |   Wednesday, 02 March 2016 05:00 PM

A commonly prescribed cardiac drug may offer hope to patients with a particularly aggressive form of breast cancer for which few treatment options exist.

Triple negative breast cancer is a rare type of tumor that comprises about 15-20 percent of all breast cancer cases.  It is also a particularly dangerous form of the disease because its cells lack receptors that are used by today’s treatments.

But a new Australian study shows that beta blockers, a commonly prescribed cardiac drug, may have the potential to slow the growth of this aggressive form of breast cancer.

When the body is under stress, the hormone adrenaline is released, which raises blood pressure and also quickens the heartbeat. Previous research also finds that adrenalin can accelerate the growth and spread of some forms of aggressive cancer.

The researchers examined how aggressive triple negative breast cancer cell responds to the adrenaline. They found that these breast cancer tumor cells have a surface protein called "beta2-adrenoceptor" that can binds both beta-blockers and the stress hormone adrenaline.

Beta blockers act by blunting the affects of adrenaline. When bound to adrenaline, the beta2-adrenoceptor on these tumor cells stimulates a positive signaling loop to accelerate invasion. When bound to beta-blocker, however, the accelerated invasion of these cells was decreased, providing a target to use in treating this type of cancer.
 
"This is excellent research that shows us that we still do not know the full potential of many of the drugs sitting in most medicine cabinets," says Dr. Thoru Pederson, editor-in-chief of The FASEB Journal, in which the study appears. "Not only does this shed light on how to potentially improve the effectiveness of triple negative cancer treatments, but it also sheds light on the full effect that these common drugs have on our bodies,” he added.




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A commonly used heart drug may have the potential to slow the growth of triple negative breast cancer, a particularly aggressive form of the disease for which few treatment options exist, a new study finds.
breast, cancer, triple, negative, slow, metatastic
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2016-00-02
Wednesday, 02 March 2016 05:00 PM
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