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Red Wine Compound Boosts Cardio Health in Diabetics: Study

Red Wine Compound Boosts Cardio Health in Diabetics: Study
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By    |   Thursday, 04 May 2017 04:10 PM

Supplements of the potent antioxidant resveratrol may reduce artery stiffness in people with Type 2 diabetes, according to a new study that may explain how the compound in red wine boosts cardiovascular health.

The research, presented this week at the American Heart Association's 2017 Scientific Sessions in Minneapolis, suggests the compound may help boost the cardiovascular health in diabetics and others.

"This adds to emerging evidence that there may be interventions that may reverse the blood vessel abnormalities that occur with aging and are more pronounced in people with Type 2 diabetes and obesity," said the new study’s senior author, Dr. Naomi M. Hamburg, of the Boston University School of Medicine.

The researchers recruited 57 obese, middle-aged patients with Type 2 diabetes. Nearly two-thirds of the participants were African-American and slightly more than half were women.

The body's largest artery, the aorta, becomes stiffer with age and illness, increasing the risk of heart attacks and strokes. To measure aortic stiffness, the researchers performed a test called the carotid-femoral pulse wave velocity (CFPWV) after patients consumed daily doses of 100 mg/day of resveratrol for two weeks followed by 300 mg/day of resveratrol for two weeks.

They performed the test again after patients underwent comparable placebo dosing for a total of four weeks.

Researchers also assessed the ability of the participants’ blood vessels to relax and expand as needed to accommodate changes in blood flow, an important indicator of healthy blood vessel function.

Overall, the researchers found that resveratrol was associated with a trend toward reduced aortic stiffness.

In a subset of 23 patients with high arterial stiffness at the start of the study, they found that the 300 mg dose of resveratrol reduced aortic stiffness by 9.1 percent and that the 100 mg dose reduced it by 4.8 percent. For those receiving a placebo, aortic stiffness actually increased.

Animal studies have shown that resveratrol activates a gene called SIRT 1 which counters the effects of obesity, delays the development of chronic diseases, and promotes longevity.

To see if a similar process occurs in humans, the researchers took a sample of the inner lining of blood vessels from seven participants and examined the tissue for SIRT1 activity. Although they detected increased SIRT1 activity after resveratrol supplementation, the difference was not statistically significant.

"We found that resveratrol also activates the longevity gene SIRT1 in humans, and this may be a potential mechanism for the supplements to reduce aortic stiffness,” said lead study author Dr. Ji-Yao Ella Zhang, Ph.D., also of the Boston University.

“However, the changes in this small and short-term study are not proof. Studies with longer treatment are needed to test the effects of a daily resveratrol supplement on vascular function."

Resveratrol belongs to a group of compounds called polyphenols that help protect the body against damage caused by free radicals.

Small amounts of resveratrol are naturally found in red wine, peanuts, berries, and the skin of red grapes. For example, a glass or red wine may contain 1-2 milligrams. Supplements of resveratrol – including those used in clinical studies – usually contain hundreds of times that amount of resveratrol.

Preliminary research – most of it conducted in animals or cell cultures – suggests that resveratrol may protect against:

Alzheimer’s disease, by protecting nerve cells and preventing the buildup of plaque.

Cancer, by preventing the metastasis (spread) of tumors and promoting the apoptosis (death) of cancer cells.

Diabetes, by reducing the risk of insulin resistance, a condition in which cells fail to respond normally to the hormone insulin, which often leads to elevated blood sugar.

Heart disease, by reducing inflammation, blood levels of LDL “bad” cholesterol, and the “stickiness” of platelets that can clump together and form clots. .

In line with previous research linking resveratrol with anti-aging effects, a recent study of rhesus monkeys shows that that compound can help counteract the adverse effects of high fat and high-sugar diet on muscle cells.

A growing number of human studies also suggests significant health benefits. For example, a recent clinical study of Alzheimer’s disease patients shows that resveratrol restores blood-brain barrier integrity, which helps prevent inflammatory molecules from entering the brain.

Another recent clinical study shows that resveratrol can help correct hormone imbalances in women with polycystic ovary syndrome (PCOS), a leading cause of infertility.

So far, researchers have not linked resveratrol to any serious side effects. But some experts believe that high daily doses (1,000 mg or more) may:

Increase the risk of bleeding, especially when taken in conjunction with blood thinners such as warfarin (Coumadin) and NSAIDs such as aspirin and ibuprofen.

Interfere with the metabolism of some commonly prescribed drugs, including statins for heart disease and benzodiazepines for anxiety.

Experts agree that more research is needed to establish resveratrol’s safety, efficacy, and optimal dosages.

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Diabetes
New research adds to growing evidence that the antioxidant resveratrol, in red wine and other foods, helps boost cardiovascular health in diabetics, and has other benefits.
red, wine, heart, diabetes, resveratrol
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2017-10-04
Thursday, 04 May 2017 04:10 PM
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