Tags: Alzheimer's/Dementia | alzheimer | treatment | drug | dementia

Old Drug Offers New Hope for Alzheimer's

Old Drug Offers New Hope for Alzheimer's
(Copyright DPC)

By    |   Wednesday, 23 September 2015 02:48 PM

A drug used to treat rheumatoid arthritis could offer a treatment for Alzheimer’s disease, a preliminary study shows.

Scientists from the Gladstone Institutes at University of California-San Francisco say they have discovered that salsalate, a drug used to treat rheumatoid arthritis, effectively lowers tau protein levels in mice. Tau protein accumulates in the neurons, or nerve cells, of the brain in people with Alzheimer’s disease.

Salsalate inhibits tau acetylation, a chemical process that can change the function and properties of a protein, the researchers said. Like aspirin, salsalate is an anti-inflammatory drug. People on aspirin have a lower risk of Alzheimer’s disease.

Salsalate successfully reversed effects in a mouse model of frontotemporal dementia, lowering tau levels in the brain, rescuing memory impairments, and protecting against atrophy of the hippocampus -- a brain region essential for memory formation that is impacted by dementia, the researchers said of the study, which appears in Nature Medicine.

The scientists say a clinical trial using salsalate to reduce tau levels in progressive supranuclear palsy, another tau-mediated neurological condition, has already been initiated.

Although tau has been a target in dementia research for some time, there are no tau-targeted drugs available for patients. Additionally, how the protein builds up in the brain, causing toxicity and contributing to disease, still remains largely a mystery, they noted.

© 2019 NewsmaxHealth. All rights reserved.

   
1Like our page
2Share
Brain-Health
A drug long used to treat rheumatoid arthritis could offer a treatment for Alzheimer's disease, a preliminary study shows. Scientists from the Gladstone Institutes at University of California-San Francisco say they have discovered that salsalate may be a promising way to combat dementia.
alzheimer, treatment, drug, dementia
220
2015-48-23
Wednesday, 23 September 2015 02:48 PM
Newsmax Media, Inc.
 

The information presented on this website is not intended as specific medical advice and is not a substitute for professional medical treatment or diagnosis. Read Newsmax Terms and Conditions of Service.

Newsmax, Moneynews, Newsmax Health, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc.

NEWSMAX.COM
© Newsmax Media, Inc.
All Rights Reserved