Tags: skin | cancer | tel aviv | melanoma

Skin Cancer: Tel Aviv Research Unlocks Secrets of Melanoma

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By    |   Wednesday, 24 Aug 2016 10:26 AM

Skin cancer research done at Tel Aviv University could lead to new treatments for melanoma after scientists there said they discovered the mechanism that lets the most aggressive and fatal form of skin cancer spread to other organs.

Researchers were able to find not only how melanoma spreads but also chemical substances that can stop the metastasizing process.

The research, published this week in the science journal Nature Cell Biology, was done by collaborators from the Tel Aviv University, the German Cancer Research Center and two other Israeli medical centers, said the Daily Beast.

The Centers for Disease Control and Prevention said 71,943 people in the United States were diagnosed with melanomas of the skin in 2013, with 9,394 dying from it. More men (42,430) were diagnosed and died (6,239) from the ailment.

"The threat of melanoma is not in the initial tumor that appears on the skin, but rather in its metastasis – in the tumor cells sent off to colonize in vital organs like the brain, lungs, liver and bones," said Dr. Carmit Levy of the Department of Human Molecular Genetics and Biochemistry at Tel Aviv's University's Sackler School of Medicine.

"We have discovered how the cancer spreads to distant organs and found ways to stop the process before the metastatic stage."

Levy and his colleague found that before melanoma spreads to other organs, a melanoma tumor sends out tiny vesicles containing molecules of microRNA. That process starts morphological changes in the dermis in preparation for receiving and transporting the cancer cells.

Researchers said they discovered that the chemical SB202190 inhibits the delivery of the vesicles from the melanoma tumor to the dermi, and that U0126 prevents the morphological changes in the dermis even after the arrival of the vesicles.

"Our study is an important step on the road to a full remedy for the deadliest skin cancer," said Levy. "We hope that our findings will help turn melanoma into a nonthreatening, easily curable disease."

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Skin cancer research done at Tel Aviv University could lead to new treatments for melanoma after scientists there said they discovered the mechanism that lets the most aggressive and fatal form of skin cancer spread to other organs.
skin, cancer, tel aviv, melanoma
329
2016-26-24
Wednesday, 24 Aug 2016 10:26 AM
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