Tags: ppi | death | rates | heartburn | drugs

PPIs' Death Rates 25 Percent Over Other Heartburn Drugs

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By    |   Wednesday, 05 Jul 2017 07:17 AM

PPIs' death rates among heartburn drug users were found to be 25 percent higher than those using other heartburn drugs, said a new study, raising concerns about popular over-the-counter brands such as Prevacid, Prilosec, and Nexium.

Researchers found that for every 500 people taking PPIs for a year, there was one extra death that would not have otherwise occurred, said the study released on Monday by the Washington University School of Medicine in St. Louis. The scientists said that given the popularity of the drugs, that could translate into thousands of excess deaths every year.

The study published in the journal BMJ Open examined the medical records of 275,000 PPI users and nearly 75,000 people who took another class of drugs – known as H2 blockers – to reduce stomach acid.

"No matter how we sliced and diced the data from this large data set, we saw the same thing: There's an increased risk of death among PPI users," said Ziyad Al-Aly, an assistant professor of medicine at Washington University and the coauthor of the study.

"For example, when we compared patients taking H2 blockers with those taking PPIs for one to two years, we found those on PPIs had a 50 percent increased risk of dying over the next five years. People have the idea that PPIs are very safe because they are readily available, but there are real risks to taking these drugs, particularly for long periods of time," said Al-Aly.

CBS News said the researchers found a "graded" relationship, meaning the longer patients took the medication — for 30 days, 60 days, 90, 120 days, a year and so on — the higher their risk of death.

The study was observational, meaning it did not show that PPIs were the cause of the increased risk of death, and that it was unclear how the drugs would act to affect mortality, according to The Guardian,

"PPIs are very effective medicines, proven to save lives and reduce the need for surgery in patients with bleeding gastric and duodenal ulcers and several other conditions," said Gareth Corbett, a gastroenterologist from Addenbrooke's Hospital in Cambridge, England, and cautioning that in most cases the benefits of PPI far outweighed any risk.

Other studies have linked PPIs to other potential health risk, like kidney disease, stomach infections, heart disease, pneumonia, bone fractures, and dementia, said CBS News.

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PPIs' death rates among heartburn drug users were found to be 25 percent higher than those using other heartburn drugs, said a new study, raising concerns about popular over-the-counter brands such as Prevacid, Prilosec, and Nexium.
ppi, death, rates, heartburn, drugs
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2017-17-05
Wednesday, 05 Jul 2017 07:17 AM
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