Tags: Cancer | vitamin D | immunity | protein | macrophage | cancer

New Immune Booster Discovered

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Wednesday, 01 Oct 2014 04:37 PM Current | Bio | Archive

I have written extensively about the critical role that vitamin D3 plays in protecting people from infections and the complications brought on by infections. New discoveries now show that even the molecule that acts as a carrier for vitamin D3 in the bloodstream is playing a considerable role in this protection.
 
This factor — called vitamin D3-binding protein or Gc protein — is the principle precursor of macrophage activating factor (MAF), which activates macrophages.
 
The macrophage is one of the most important immune cells because it directs a number of other immune cells, giving them orders during immune attacks on invaders like a general in a battle. When the immune system is called upon (as with infections or the development of cancer) Gc protein is converted into MAF. This, in turn, stimulates the body to recruit huge numbers of fully activated macrophages for battle.
 
This can mean the difference between life and death. Unfortunately, many bacteria, viruses, and fungi contain within their cell walls a special enzyme called nagalase (Nacetylgalactosaminidase), which prevents MAF from being produced from Gc protein.
 
In essence, the infectious invader or cancer is disarming the immune system. Researchers are now developing ways to neutralize nagalase and enhance the production of MAF, which will give doctors a very powerful weapon against infections and cancers.
 
Dr. Nobuto Yamamoto, of the Division of Molecular Immunology and Immunotherapy at the Socrates Institute for Therapeutic Immunology in Philadelphia (the discoverer of Gc/MAF), has tested MAF on a number of patients with advanced cancers and out-of-control infections. He found that cancer patients frequently have high levels of nagalase and low MAF, which allows the cancer to evade their immune systems.
 
In testing MAF infusions on a group of patients with advanced prostate cancer, Dr. Yamamoto found that the patients remained tumor-free with no evidence of recurrence for seven years of follow-up. The infusions only had a few minor side effects.
 
In other studies, the MAF infusion was tested on patients with colorectal and breast cancers, and again showed the same long-term benefits.
 
The prognosis of many cancers can be predicted by measuring levels of nagalase, which go up as the cancer grows and spreads. The nagalase enzyme is not seen in healthy people; it is produced by the cancer cells themselves. Researchers have also found that they could measure a patient’s response to conventional treatments by measuring nagalase.
 
If the treatment is killing the tumor, nagalase levels fall. They will rise again just before the tumor reoccurs.
 

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Dr-Blaylock
New discoveries show that even the molecule that acts as a carrier for vitamin D3 in the bloodstream is playing a considerable role in protecting people from infections and the complications brought on by infections.
vitamin D, immunity, protein, macrophage, cancer
413
2014-37-01
Wednesday, 01 Oct 2014 04:37 PM
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