Tags: bioavailability | vitamin C | CoQ10 | nanosizing

Improving Supplement Absorption

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Wednesday, 22 Jul 2015 04:45 PM Current | Bio | Archive

Bioavailability refers to the ability of a drug or supplement to get to cells or tissues, where it can produce the beneficial effects that people want.

Because bioavailability is so critical to the effective use of supplements, a number of new methods for improving absorption and distribution of supplements have been created by some of the more innovative companies.

For example, we know that there is a limit to the amount of vitamin C that can be absorbed and retained by the body.

Once this limit is reached, the rest is excreted into the bowel. (This is why high vitamin C intake can result in diarrhea.)

To overcome this response, scientists encapsulated the vitamin C molecules in microscopic capsules of fat (usually phospholipids such as phosphatidylcholine). This allows a much higher concentration of vitamin C to be absorbed by the body.

Vitamin C itself is water-soluble, and inside cells it is limited to the watery parts of the cells. But lipid-encapsulated vitamin C can enter the membrane of other compartments of the cell, where it can provide even more protection.

Another way to improve bioavailability is to break supplement molecules into much smaller parts.

Most supplements exist as clumps of molecules, which can make them difficult to absorb. But when they are broken down into micron-size particles, it can greatly improve absorption.

Indeed, there are now even smaller, nanosize particles, available for some supplements — making them even more bioavailable. This also allows people to use smaller doses of supplements because more of the active substances are getting to the beneficial area of the body — even the brain — than would if the supplement were consumed in a powder form.

For example, 100 mg of the nanosize form of coenzyme Q10 (CoQ10) is equivalent to several
hundred milligrams of the older powdered product.

Nanosizing can also turn a lipid-soluble supplement into one that dissolves both in lipids and water, which greatly improves gut absorption and distribution in the body.

Nanosizing also overcomes one of the biggest problems for users of natural products — getting
beneficial substances into the brain.

Nanosize products can reach much higher levels in the brain, entering all parts of brain cells better than conventional forms.

Because nanosizing so greatly improves the absorption of poorly absorbed products, such as many of the flavonoids, it means that supplements can be put in smaller capsules.

This means that users can obtain equal or even better results with smaller, less expensive doses than they do when using traditional supplements.

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Dr-Blaylock
A number of new methods for improving absorption and distribution of supplements have been created by some of the more innovative companies.
bioavailability, vitamin C, CoQ10, nanosizing
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2015-45-22
Wednesday, 22 Jul 2015 04:45 PM
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