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Chronic Kidney Disease Spikes Death Risk

Friday, 28 Sep 2012 11:45 AM


Two new studies have found chronic kidney disease can be a strong indicator of the risk of death and end-stage renal disease, even in people without high blood pressure or diabetes.
The studies, by the Johns Hopkins Bloomberg School of Public Health and the Chronic Kidney Disease Prognosis Consortium, noted hypertension and diabetes are common conditions in chronic kidney disease patients. But the new findings, published in The Lancet, suggest low kidney function – by itself – significantly raises the risk of death due to cardiovascular disease.
"Chronic kidney disease should be regarded as at least an equally relevant risk factor for mortality and [end stage kidney disease] in individuals without hypertension as it is in those with hypertension," said lead researcher Dr. Bakhtawar K. Mahmoodi.
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Chronic kidney disease affects up to 16 percent of Americans and is typically detected by measuring albumin, a protein in urine.
For the latest study, researchers analyzed past research on low kidney function and high urine protein and found a clear link to cardiovascular mortality in individuals with and without hypertension. The results showed individuals with diabetes had a higher risk of cardiovascular mortality and end stage kidney disease, compared to those without diabetes.
"These data provide support for clinical practice guidelines which stage chronic kidney disease based on kidney function and urine protein across all causes of kidney disease,” said Dr. Josef Coresh, a professor in the Bloomberg School's Department of Epidemiology. “The conclusions are strengthened by the findings of leading studies and the participation of investigators from 40, countries and a detailed analysis of over 1 million participants.”
The study was funded, in part, by the U.S. National Kidney Foundation and the National Institutes of Health.
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Chronic kidney disease ups the risk of death, even in people without high blood pressure or diabetes.
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2012-45-28
Friday, 28 Sep 2012 11:45 AM
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