Tags: heart | depression | marker

Heart Disease Biomarker Linked to Depression

Friday, 28 Dec 2012 11:06 AM


People with elevated levels of a biomarker linked to inflammation and heart disease also appear to be more prone to depression, new Danish research shows.
The study, published online in the Archives of General Psychiatry, found people with high levels of so-called “C-reactive protein” (CRP) are far more likely to experience “psychological distress” than the general population. The findings suggest low-grade inflammation in the body may contribute to the development of depression, a leading cause of disability, and anti-inflammatory drugs may offer a new treatment option.
"The main finding of this study consisted of an association of elevated CRP levels with an increased risk for psychological distress and depression in the general population," said lead researcher Marie Kim Wium-Andersen, M.D., of Herlev Hospital and Copenhagen University Hospital, Denmark.
"More research is needed to establish the direction of the association between CRP and depression because this study … [but] the results also support the initiation of intervention studies to examine whether adding anti-inflammatory drugs to antidepressants for treatment of depression will improve outcome."
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CRP is a commonly used marker of inflammation or swelling somewhere in your body. Doctors typically check it after surgery or treatment for infections, and to evaluate your risk of developing coronary artery disease, which can lead to a heart attack.
For the study, researchers analyzed CRP levels in the blood of 73,131 men and women — ages 20 to 100 years — who participated in two health studies in Copenhagen. They also tracked the study participants’ mental-health histories.
The results showed increased CRP levels were associated with a greater risk for psychological distress and depression.


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People with elevated levels of a biomarker linked to inflammation and heart disease are also more prone to depression.
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2012-06-28
Friday, 28 Dec 2012 11:06 AM
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