Tags: flavonoid | blood | clots

Flavonoid Prevents Blood Clots

Thursday, 10 May 2012 11:35 AM


Rutin – a flavonoid compound found in fruits and vegetables and sold as a dietary supplement -- has been shown to block blood clots in new animal studies that have significant implications for people.
The study, led by investigators at Beth Israel Deaconess Medical Center and published in the Journal of Clinical Investigation, suggests the compound may offer a potential new therapeutic strategy to prevent stroke, heart attack and other dangers posed by blood clots.
"It's not always fully appreciated that the majority of Americans will die as the result of a blood clot in either their heart or their brain," said lead researcher Dr. Robert Flaumenhaft, a medical specialist at Harvard Medical School. "Approximately half of all morbidity and mortality in the United States can be attributed to heart attack or stroke."
For the study, Flaumenhaft and his colleagues examined the effects of rutin on a protein – known as disulfide isomerase (PDI) -- released when a clot forms in a blood vessel. They found rutin stopped the secretion of PDI and, as a result, blocked the formation of blood clots.
Rutin is a bioflavonoid naturally found in many fruits, vegetables and teas. It is also sold as an herbal supplement, having received a special designation for safety from the U.S. Food and Drug Administration.
Despite the use of existing anti-clotting therapies -- such as aspirin, Plavix and warfarin (Coumadin) – about 400,000 people suffer second strokes or heart attacks each year, said Flaumenhaft.
"A safe and inexpensive drug that could reduce recurrent clots could help save thousands of lives," he added. "These pre-clinical trials provide proof-of-principle that PDI is an important therapeutic target for anti-thrombotic therapy."


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Natural compound found in fruits and vegetables and sold in supplements found to block blood clots.
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2012-35-10
Thursday, 10 May 2012 11:35 AM
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