Tags: fat | women | weight | hormone

Fat, Hormones Tied to Weight Gain

Monday, 10 Sep 2012 11:18 AM


A high-fat diet may trigger gender-specific interactions with women’s hormones to boost greater levels of abdominal weight gain than men as they age, new research suggests.
The findings, based on studies of laboratory mice, may explain why women are more likely than men to develop belly fat after eating excess saturated fat – particularly after menopause.
Ohio State University scientists found fatty foods activate an enzyme that leads to the formation of fat in women that accumulates around internal organs and is linked to a higher risk for type 2 diabetes, heart disease and cancer.
When researchers genetically altered the mice in the study by deleting the enzyme – Aldehyde Dehydrogenase 1 – they stayed lean, especially in the abdominal area, even when they continued to eat a lot of fat. The effect was far less significant in males than females. Researchers also noted estrogen suppresses the enzyme's activity, which might explain why postmenopausal women, whose estrogen levels decline, tend to accumulate fat in their bellies.
Researchers said the findings in mice have significant implications for women because the same processes occur in human beings.
The study, published online in the journal Diabetes, could point the way to new anti-obesity therapies for women based on the enzyme.
"If you asked most people what they believe causes obesity, they would probably say high food consumption and a sedentary lifestyle. But we see that there are genetic factors telling the body what to do with fat," said lead researcher Ouliana Ziouzenkova. "A high-fat diet acts on our genetics to make us more fat or less fat. The diet is not powerful enough to do this on its own."


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A high-fat diet interacts with women's hormones to boost belly weight as they age.
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2012-18-10
Monday, 10 Sep 2012 11:18 AM
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