Tags: dna | heart | disease | men | y | chromosome

DNA, Heart Disease Linked in Men

Thursday, 09 Feb 2012 03:39 PM

Up to one in five men with European ancestry carry a version of the male chromosome that increases their risk of heart disease by 50 percent, scientists reported Thursday.
The study, published by University of Leicester researchers in The Lancet, involved analyzing more than 3,200 British men's DNA over a four-year period. What they found is that 90 percent of male chromosomes belonged to two major groups, one of which – identified as the haplogroup I group – increase the risk of heart disease by 50 percent.
“The human Y chromosome is associated with risk of coronary artery disease in men of European ancestry, possibly through interactions of immunity and inflammation,” the researchers concluded.

They noted that lifestyle factors – smoking, high cholesterol, obesity – increase the risk of heart disease. But the new findings also show inherited genetic variations in the Y chromosome are another piece of the puzzle and may partly explain why heart disease runs in families.

Health experts said research should now turn to potential treatments based on the findings and the development of tests that could identify men at higher risk of heart disease – the leading cause of death in the United States.

© HealthDay

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1 in 5 men with European ancestry carry a version of the Y chromosome that increases their heart disease risk.

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