Tags: antibiotics | increase | miscarriage | risk

Common Antibiotics Tied to Increased Miscarriage Risk

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By    |   Monday, 01 May 2017 11:18 AM

Common antibiotics, such as tetracyclines and sulfonamides, increase the risk of miscarriage by up to 200 percent early in pregnancy, says a new study published in CMAJ (Canadian Medical Association Journal).

"Infections are prevalent during pregnancy," said Dr. Anick Bérard, Faculty of Pharmacy, Université de Montréal, Montréal, Quebec. "Although antibiotic use to treat infections has been linked to a decreased risk of prematurity and low birth weight in other studies, our investigation shows that certain types of antibiotics are increasing the risk of spontaneous abortion, with a 60 percent to two-fold increased risk."

Bérard and her team studied data from the Quebec Pregnancy Cohort between 1998 and 2009. For this study, 8,702 cases, defined as clinically detected spontaneous abortions, were matched with 87,020 controls; mean gestational age at the time of miscarriage was 14 weeks of pregnancy.

A total of 1,428 (16.4 percent) of the cases of miscarriage were exposed to antibiotics during early pregnancy compared to 11,018 (12.6 percent) in controls.

Women who miscarried were more likely to be older, living alone and to have multiple health issues and infections, all of which were taken into account in the analyses.

"Given that the baseline risk of spontaneous abortion can go as high as 30 percent, this is significant," said Bérard. "Nevertheless, the increased risk was not seen for all antibiotics, which is reassuring for users, prescribers and policy-makers."

Although the risky antibiotics included macrolides, quinolones, tetracyclines, sulfonamides and metronidazole, neither erythromycin nor nitrofurantoin, often used to treat urinary tract infections in pregnant women, were associated with increased risk.

The researchers hope that their findings may be helpful for policy-makers to update guidelines for the treatment of infections during pregnancy.

A miscarriage is defined as a pregnancy that ends on its own within the first 20 weeks of gestation. According to the American College of Obstetricians and Gynecologists, 10 to 25 percent of all diagnosed pregnancies end in miscarriage. There are more than 3 million miscarriages in the United States every year.

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Common antibiotics, such as tetracyclines and sulfonamides, increase the risk of miscarriage by up to 200 percent early in pregnancy, says a new study published in CMAJ (Canadian Medical Association Journal). "Infections are prevalent during pregnancy," said Dr. Anick...
antibiotics, increase, miscarriage, risk
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2017-18-01
Monday, 01 May 2017 11:18 AM
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