Tags: allergic | reactions | anaphylaxis | estradiol | estrogen

Estrogen Increases Severe Allergic Reactions

Monday, 29 Dec 2014 11:49 AM


 
Medical professionals know that women frequently have more severe allergic reactions than men, and the reason may be estradiol, a type of estrogen.

Anaphylaxis is an allergic reaction triggered by food, medication, or insect stings and bites. Immune cells release enzymes that cause tissues to swell and blood vessels to widen. The result may be skin flushing, rashes, or problems breathing. In extreme cases, the victim may experience shock or a heart attack. Studies have shown that women have anaphylaxis more frequently than men, but scientists didn't understand why.

In a mouse study, researchers from the National Institute of Allergy and Infectious Diseases (NIAID), which is a part of the National Institutes of Health (NIH), found that estradiol increases levels of an enzyme called oxide synthase (eNOS), which drives life-threatening allergic reactions, causing some of the problems of anaphylaxis. When researchers blocked the activity of eNOS, the severity of allergic reactions in female mice lessened, and their allergic responses became similar to those of male mice.

If the same effects can be replicated in people, scientists may be able to develop preventive therapies.

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Medical professionals know that women frequently have more severe allergic reactions than men, and the answer may be estradiol, a type of estrogen. Anaphylaxis is an allergic reaction triggered by food, medication, or insect stings and bites. Immune cells release enzymes...
allergic, reactions, anaphylaxis, estradiol, estrogen
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2014-49-29
Monday, 29 Dec 2014 11:49 AM
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