Tags: genes | Alzheimers | APOE- 4

Genetics Just One Part of Alzheimer's

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Thursday, 02 Feb 2017 04:31 PM Current | Bio | Archive

Although science has made tremendous strides improving diagnosis and treatment to slow the progression of Alzheimer’s, no cure or disease-modifying intervention has yet been discovered.

In the past three decades, however, a better understanding of the genetic contributions to the disease has emerged.

Besides genetic mutations that cause early-onset Alzheimer’s in rare cases, scientists have identified genetic risks that affect the general population.

In most cases, genetics contributes to the risk but doesn’t actually cause the disease.

For example, one 1 in 5 people carry the APOE- 4 gene for Alzheimer’s.

But the gene is neither necessary nor sufficient for developing the disease. Many with APOE-4 never get Alzheimer’s, while some people without APOE-4 develop the disease.

Genetics is just one part of what determines the likelihood of developing Alzheimer’s.

In fact, the large MacArthur Study of Successful Aging suggested that nongenetic factors have more influence in determining cognitive and physical health as we age.
 

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Many with APOE-4 never get Alzheimer’s, while some people without APOE-4 develop the disease.
genes, Alzheimers, APOE- 4
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2017-31-02
Thursday, 02 Feb 2017 04:31 PM
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