Tags: Botanical | Formula | Slows | Breast | Cancer | Metastasis

Botanical Formula Slows Breast Cancer Metastasis

Monday, 21 May 2012 12:14 PM

Scientists at Indiana University Health's Cancer Research Laboratory have found that a sophisticated botanical formula slows human breast cancer growth and inhibits breast-to-lung metastasis in mice. The formula contains natural extracts from medicinal mushrooms, medicinal herbs, and purified nutritional compounds, and showed no toxic side-effects.
“Our results are very exciting because we clearly demonstrate the suppression of breast-to-lung cancer metastasis associated with the inhibition of specific pro-metastatic genes in human tumors,” says Daniel Sliva, Ph.D., Associate Professor at the Indiana University School of Medicine and lead author on the study.
Up to 25 percent of breast cancer is classified as triple negative, and it is difficult to treat. It's not fueled by estrogen or progesterone or the HER2 protein, so the most effective chemotherapy drugs, such as Herceptin, aromatase inhibitors, and selective estrogen receptor modulators, aren't effective.
In the Indiana study, researchers implanted highly invasive, triple-negative human breast cancer cells (MDA-MB-231) in mice, which were then given the botanical formula orally for four weeks.
The formula significantly decreased the growth of tumors and the spread of cancer from the breast to the lungs (mestastasis). The cancer metastasized to the lungs in 70 percent of controls but only 20 percent of treated mice. The number of metastases per animal was also significantly reduced by the formula.
When the researchers investigated further, they found that the formula slowed two tumor genes PLAU (urokinase plasminogen activator, uPA) and CXCR4 (C-X-C chemokine receptor-4), which have been linked to metastasis.
“Patients with breast cancer die from metastasis,” said formula inventor and study co-author Isaac Eliaz, M.D. “This formula was able to change the gene expression of highly aggressive metastatic breast cancer and dramatically decrease the deadly metastatic process.”
The formula uses a variety of natural compounds which have shown anti-cancer abilities. Mycelium from medicinal mushrooms Coriolus versicolor, Ganoderma lucidum, and Phellinus linteus reduced growth and invasiveness. Extracts from Scutellaria barbata, Astragalus membranaceus, and Curcuma longa have been shown to induce programmed cell death (apoptosis) and to reduce metastasis. The flavonoid quercetin reduced proliferation and helped suppress tumor growth. In addition, 3, 3’-Diindolylmethane (DIM), an active byproduct of cruciferous vegetable digestion, reduced cancer growth, migration, and invasiveness.
“This formula may be considered as a biological therapeutic agent against invasive breast cancer, including the aggressive triple negative breast cancer," said Dr. Sliva. "It can potentially increase survival of breast cancer patients.”


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Scientists at Indiana University Health's Cancer Research Laboratory have found that a sophisticated botanical formula slows human breast cancer growth and inhibits breast-to-lung metastasis in mice.
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2012-14-21
Monday, 21 May 2012 12:14 PM
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