A large UPS cargo plane crashed early Wednesday morning near the airport in Birmingham, Alabama, killing the pilot and co-pilot, the city's mayor said.
"I can confirm they were killed in the crash," said Birmingham Mayor William Bell.
A fire in a sparsely populated area that broke out after the crash was "under control," he said, adding that there were no other casualties.
United Parcel Service Inc flight 1354, en route from Louisville, Kentucky, to Birmingham, crashed on approach about 6 a.m. (1000 GMT), according to the FAA. The plane was identified as an Airbus A300.
UPS, the world's largest package-delivery company, said it was "still determining the details of the incident."
An Airbus spokesman in Toulouse, France, said he had no information on the incident.
It was the latest in a series of air accidents in the United States in recent months.
In July, an Asiana Airlines Boeing 777 crashed while landing in San Francisco, killing three people and injuring more than 180.
Also last month, the front landing gear of a Southwest Airlines Co Boeing 737 jet collapsed on touchdown at New York City's LaGuardia Airport, injuring eight.
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