Tags: fungi | stomach | ailments

Fungi Gone Awry in Gut May Contribute to Intestinal Diseases

Wednesday, 06 Jun 2012 03:34 PM

 

Share:
  Comment  |
   Contact Us  |
  Print  
|  A   A  
  Copy Shortlink

The intestinal tract, home to 100 trillion bacteria, also hosts a bevy of fungi that may contribute to inflammatory bowel ailments like Crohn’s disease and colitis, a study suggests.

Researchers at Cedars-Sinai Medical Center in Los Angeles found 200 different types of fungi in the guts of mice, half of which they couldn’t name, according to a report in the journal Science. They also uncovered a genetic variation in a protein called Dectin-1 that helps white blood cells recognize and kill fungi. Mice with the variation had more inflammation.

Future research may yield similar results in people, said David Underhill, director of Cedars-Sinai Medical Center’s graduate program in biomedical science and translational medicine. The researchers suggested the fungi may also play a role in ulcerative colitis, a disease marked by ulcers in the lining of the large intestine. Patients with a variant in the Dectin-1 gene had more severe disease, the study found.

“We can speculate wildly about whether immunity to the fungi in the gut, or altered immunity to fungi in the gut, is playing a role in the severity of the disease,” Underhill said in a telephone interview. “Further studies are required to determine in humans if that’s the case.”

The research shows the gene is important for controlling inflammation in animals like mice, said Underhill, the paper’s lead author. It may take years to figure out if it’s really a defective version of the gene of if something else is going on.

“We have recently developed a rich and growing understanding of how the immune system interacts with bacteria in the gut,” Underhill said. “This study will encourage folks to consider as well how the immune system is interacting with the fungal community in the gut.”

 

© Copyright 2014 Bloomberg News. All rights reserved.

Share:
  Comment  |
   Contact Us  |
  Print  
  Copy Shortlink
Around the Web
Join the Newsmax Community
>> Register to share your comments with the community.
>> Login if you are already a member.
blog comments powered by Disqus
 
Email:
Retype Email:
Country
Zip Code:
 
Hot Topics
Follow Newsmax
Like us
on Facebook
Follow us
on Twitter
Add us
on Google Plus
Around the Web
You May Also Like

SpaceX Launches Supplies Rocket to International Space Station

Friday, 18 Apr 2014 21:25 PM

The SpaceX company returned to orbit Friday, launching fresh supplies to the International Space Station after more than . . .

Cool Heels on Climate Change Actions, Skeptics Say

Friday, 18 Apr 2014 15:08 PM

A report from the Intergovernmental Panel on Climate Change has been seized upon by the Obama administration and environ . . .

New Technique to Grow Stem Cells Could Lead to Cloning

Friday, 18 Apr 2014 10:45 AM

Experts warned that a new technique allowing stem cells to be grown from the DNA of human adult males could lead to huma . . .

Newsmax, Moneynews, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, NewsmaxWorld, NewsmaxHealth, are trademarks of Newsmax Media, Inc.

 
NEWSMAX.COM
America's News Page
©  Newsmax Media, Inc.
All Rights Reserved