Study: New Blood Thinner Raises Risk of Sudden Death

Tuesday, 02 Apr 2013 04:42 PM

By Nick Tate

  Comment  |
   Contact Us  |
|  A   A  
  Copy Shortlink
Pradaxa, a newly approved blood thinner, has been linked an increased risk of sudden death, as well as certain viral illnesses, including flu and myocarditis, a viral infection of the heart.
In research involving laboratory mice, scientists at the University of North Carolina found that Pradaxa (Dabigatran etexilate), approved recently by the U.S. Food and Drug Administration to treat patients with irregular heart rhythms, can pose a greater risk of heart and viral dangers, suggesting it may interfere with certain processes in the body.
For 50 years, people with the heartbeat irregularity, atrial fibrillation, and others at risk of developing life-threatening blood clots have been given the anticoagulant drug warfarin. Recently, the FDA approved Pradaxa as an alternative. The drug inhibits thrombin, the body's primary clotting agent.
But in blocking thrombin activity, the drug also may also interfere with other beneficial processes involved in the body’s immune system, according to the new study, published in the Journal of Clinical Investigation.

"Our findings show that blocking thrombin reduces the innate immune response to viral infection," said Nigel Mackman, director of the UNC McAllister Heart Institute who helped conduct the study. "The use of the new generation of blood thinners might increase the risk and severity of flu and myocarditis."
Mackman noted that viral infections trigger blood-clotting activity and that helps activate other immune system functions.
For the study, Mackman and colleagues studied the effects of Pradaxa on mice infected with a virus that causes myocarditis. The results showed treated mice had greater levels of cardiac virus and heart damage.
The study was funded, in part, by the National Heart, Lung and Blood Institute of the National Institutes of Health

© 2014 NewsmaxHealth. All rights reserved.

  Comment  |
   Contact Us  |
  Copy Shortlink
Around the Web
Join the Newsmax Community
Please review Community Guidelines before posting a comment.
>> Register to share your comments with the community.
>> Login if you are already a member.
blog comments powered by Disqus
Zip Code:
Privacy: We never share your email.
Hot Topics
Follow Newsmax
Like us
on Facebook
Follow us
on Twitter
Add us
on Google Plus
Around the Web
Top Stories
You May Also Like

Americans Still Eat Too Much Trans Fat: Study

Wednesday, 22 Oct 2014 16:39 PM

Between 1980 and 2009, Americans' consumption of trans fat dropped by about a third and intake of saturated fats decline . . .

Binge Drinking Raises Men's Blood Pressure: Study

Tuesday, 21 Oct 2014 16:56 PM

Binge drinking among young adult men may lead to increased blood pressure, according to a new study.
But binge drin . . .

Ford Car Seat Detects Heart Attacks

Monday, 20 Oct 2014 13:00 PM

With the world's population aging, companies are busily developing products that appeal to wealthy people over the age o . . .

Most Commented

Newsmax, Moneynews, Newsmax Health, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc.

America's News Page
©  Newsmax Media, Inc.
All Rights Reserved