Heart Failure Drug Shows Promise

Monday, 02 Sep 2013 10:28 AM

 

Share:
  Comment  |
   Contact Us  |
  Print  
|  A   A  
  Copy Shortlink
An experimental drug from Novartis to treat heart failure proved equally effective regardless of the age of patients or whether they had other medical problems, clinical trial results presented on Monday showed.

The drug, serelaxin, which is a form of a human hormone that relaxes blood vessels and eases stress on the heart and other organs, is viewed as an important medicine in the Swiss drugmaker's developmental pipeline.

Analysts at Jefferies expect the drug to generate peak sales of $1.5 billion a year.

Results from a Phase III study last November found it reduced deaths by 37 percent compared with placebo - and the latest data offers further insight by showing how it performed in different patient sub-groups.

The drug led to reduced dyspnea, or breathlessness, and fewer deaths after six months in all patient groups, including those with impaired kidney function, those aged 75 or older, and those with atrial fibrillation, or irregular heartbeats.

The new findings were presented at the European Society of Cardiology congress in Amsterdam, where heart doctors have highlighted the enormous need for new treatments for acute heart failure, in which the heart is unable to pump enough blood.

Some 2 million patients are hospitalized each year in Europe and United States as a result of heart failure, and about half of all patients die within five years of being diagnosed with the condition.

Medical treatment of heart failure has changed little since the 1970s but Novartis hopes serelaxin will soon offer cardiologists a new therapy option.

U.S. regulators in June gave serelaxin "breakthrough therapy" status, potentially fast-tracking its development and approval.

The Novartis drug is currently being assessed by health authorities around the world, including the U.S. Food and Drug Administration and the European Medicines Agency.

Novartis previously disclosed that while serelaxin met one of the study's two primary goals by reducing deaths and relieving dyspnea, it failed to hit a secondary combined objective of lowering cardiovascular death and reducing the need for patients to go back into hospitals.

Researchers view the life-saving benefit as the more important measure, although many still want to see further evidence of the drug's performance given past disappointments in the field.

© 2014 Thomson/Reuters. All rights reserved.

Share:
  Comment  |
   Contact Us  |
  Print  
  Copy Shortlink
Around the Web
Join the Newsmax Community
Please review Community Guidelines before posting a comment.
>> Register to share your comments with the community.
>> Login if you are already a member.
blog comments powered by Disqus
 
Email:
Retype Email:
Country
Zip Code:
Privacy: We never share your email.
 
Follow Newsmax
Like us
on Facebook
Follow us
on Twitter
Add us
on Google Plus
Around the Web
Top Stories
You May Also Like

Twitter Helps Pinpoint Food Poisoning Sources

Wednesday, 27 Aug 2014 08:03 AM

When Chicago health officials saw Twitter users complaining about local food poisoning episodes, they reached out on Twi . . .

Ebola Workers Lack Protective Gear: WHO

Wednesday, 27 Aug 2014 07:53 AM

Health care workers in poor nations often do not have enough protective gear to keep them safe from being infected with  . . .

Heart Study Participants Don't Reflect Real-World Patients

Wednesday, 27 Aug 2014 07:46 AM

People who take part in clinical trials of new heart disease treatments are generally younger and healthier than the typ . . .

Most Commented

Newsmax, Moneynews, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, NewsmaxWorld, NewsmaxHealth, are trademarks of Newsmax Media, Inc.

 
NEWSMAX.COM
America's News Page
©  Newsmax Media, Inc.
All Rights Reserved