Scientists Discover Ovarian Cancer 'Off Switch'

Friday, 02 Aug 2013 01:18 PM

By Nick Tate

Share:
  Comment  |
   Contact Us  |
  Print  
|  A   A  
  Copy Shortlink
British scientists have discovered a molecular "on/off switch" for certain types of ovarian and testicular cancers — a finding that could point the way to new drug treatments.
 
The discovery, published in the journal Cancer Research, involves so-called "malignant germ cell tumors" that develop in sperm- or egg-forming cells in the body’s reproductive organs, both in childhood and adulthood.
 
Researchers called the findings important because current chemotherapy treatments for such cancers, while effective, can have severe side effects, including hearing loss and damage to the kidneys, lungs, and bone marrow.
 
"We need new ways of treating patients with malignant germ cell tumors, to minimize the toxic effects of chemotherapy and to improve survival rates when tumors are resistant to treatment," said Nick Coleman, a professor of molecular pathology at Cambridge University who helped make the discovery. "Having identified this 'on/off' switch, it will now be important to identify new drugs that can be used to keep it in the 'off' position."
 
Coleman and his colleagues found that all malignant germ cell tumors contain large amounts of a protein called LIN28, which causes a chain reaction that encourages cancer growth — in effect, acting as an "on switch" that promotes malignancy. By reducing amounts of the protein LIN28, the researchers found they could essentially "turn off" tumor growth.
 
"The switch effect that we have discovered is present in all malignant germ cell tumors, whether they occur in males or females, young or old," said Matthew Murray, M.D. "Such a fundamental abnormality makes an excellent new target for treating these tumors."

© 2014 NewsmaxHealth. All rights reserved.

Share:
  Comment  |
   Contact Us  |
  Print  
  Copy Shortlink
Around the Web
Join the Newsmax Community
>> Register to share your comments with the community.
>> Login if you are already a member.
blog comments powered by Disqus
 
Email:
Retype Email:
Country
Zip Code:
 
Hot Topics
Follow Newsmax
Like us
on Facebook
Follow us
on Twitter
Add us
on Google Plus
Around the Web
You May Also Like

Whoopi Goldberg Sings Praises of Pot for Glaucoma Relief

Thursday, 17 Apr 2014 16:54 PM

Oscar-winning actress, comedienne and talk-show host Whoopi Goldberg sang the praises of marijuana inhaled through a poc . . .

Seniors Show Success in Kicking Sleeping Pill Habit

Thursday, 17 Apr 2014 16:29 PM

Older people are willing and able to get themselves off medications like sleeping pills once they're informed of the pot . . .

Web Surfing Fights Depression: Study

Thursday, 17 Apr 2014 16:19 PM

Surfing the Web may ward off depression among retirees, particularly among those who live alone, according to new resear . . .

Newsmax, Moneynews, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, NewsmaxWorld, NewsmaxHealth, are trademarks of Newsmax Media, Inc.

 
NEWSMAX.COM
America's News Page
©  Newsmax Media, Inc.
All Rights Reserved