Scientists Discover Ovarian Cancer 'Off Switch'

Friday, 02 Aug 2013 01:18 PM

By Nick Tate

Share:
  Comment  |
   Contact Us  |
  Print  
|  A   A  
  Copy Shortlink
British scientists have discovered a molecular "on/off switch" for certain types of ovarian and testicular cancers — a finding that could point the way to new drug treatments.
 
The discovery, published in the journal Cancer Research, involves so-called "malignant germ cell tumors" that develop in sperm- or egg-forming cells in the body’s reproductive organs, both in childhood and adulthood.
 
Researchers called the findings important because current chemotherapy treatments for such cancers, while effective, can have severe side effects, including hearing loss and damage to the kidneys, lungs, and bone marrow.
 
"We need new ways of treating patients with malignant germ cell tumors, to minimize the toxic effects of chemotherapy and to improve survival rates when tumors are resistant to treatment," said Nick Coleman, a professor of molecular pathology at Cambridge University who helped make the discovery. "Having identified this 'on/off' switch, it will now be important to identify new drugs that can be used to keep it in the 'off' position."
 
Coleman and his colleagues found that all malignant germ cell tumors contain large amounts of a protein called LIN28, which causes a chain reaction that encourages cancer growth — in effect, acting as an "on switch" that promotes malignancy. By reducing amounts of the protein LIN28, the researchers found they could essentially "turn off" tumor growth.
 
"The switch effect that we have discovered is present in all malignant germ cell tumors, whether they occur in males or females, young or old," said Matthew Murray, M.D. "Such a fundamental abnormality makes an excellent new target for treating these tumors."

© 2014 NewsmaxHealth. All rights reserved.

Share:
  Comment  |
   Contact Us  |
  Print  
  Copy Shortlink
Around the Web
Join the Newsmax Community
Please review Community Guidelines before posting a comment.
>> Register to share your comments with the community.
>> Login if you are already a member.
blog comments powered by Disqus
 
Email:
Country
Zip Code:
Privacy: We never share your email.
 
Hot Topics
Follow Newsmax
Like us
on Facebook
Follow us
on Twitter
Add us
on Google Plus
Around the Web
Top Stories
You May Also Like

Should Prisoners Get Pricy Hepatitis C Drug?

Tuesday, 21 Oct 2014 17:06 PM

When prisoners have hepatitis C, treating them with expensive new antiviral drugs makes fiscal sense despite the hefty p . . .

Binge Drinking Raises Men's Blood Pressure: Study

Tuesday, 21 Oct 2014 16:56 PM

Binge drinking among young adult men may lead to increased blood pressure, according to a new study.
But binge drin . . .

Lack of Sleep Raises Colitis Risk

Tuesday, 21 Oct 2014 16:55 PM

New research shows chronic sleep loss increases the risk of developing ulcerative colitis. . . .

Most Commented

Newsmax, Moneynews, Newsmax Health, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc.

 
NEWSMAX.COM
America's News Page
©  Newsmax Media, Inc.
All Rights Reserved