Genetic Cause Found for Clogged Arteries

Thursday, 07 Feb 2013 12:22 PM

 

Share:
  Comment  |
   Contact Us  |
  Print  
|  A   A  
  Copy Shortlink
A genetic variation doubles the risk of developing calcium deposits in the heart, a common condition that, in severe cases, can narrow or block the aorta, according to a study published Wednesday.
 
The genetic variation, found in 7 percent of the population, provides important clues about how to treat the disease, researchers said in the study published in the New England Journal of Medicine.
 
"This is an important step forward in understanding the biology of the development of aortic stenosis," said senior author Wendy Post, from the Johns Hopkins University School of Medicine.
 
She added that the latest findings could lead to the development of targeted medications to slow the progression of the disease, which can cause chest pain and shortness of breath, and can in some cases require surgery.
 
The gene in question is involved in the production of a type of cholesterol particle called lipoprotein (a), which circulates in the blood.
 
"Increased levels of lipoprotein (a) have been previously associated with aortic valve disease. However, prior studies could not differentiate whether it was simply a marker or a causal factor," said lead author Catherine Campbell, of Kaiser Permanente.
 
"Our results provide the first evidence for a causal relationship," she added.
 
The researchers studied 2.5 million gene variants among more than 6,900 people of white European heritage, and they found that the particular variant was strongly associated with the aortic calcium deposits.
 
The scientists then confirmed the link in studies with three other groups — more than 2,000 people of Hispanic origin, about 2,500 African-Americans, and more than 700 Germans.
 
They also demonstrated that the gene variant was linked to a future risk of developing the heart condition, using data from nearly 40,000 people in Sweden and Denmark.
 
Other risk factors for developing aortic stenosis include advancing age, high blood pressure, obesity, high cholesterol levels and smoking. Men are at higher risk than women.

© AFP 2014

Share:
  Comment  |
   Contact Us  |
  Print  
  Copy Shortlink
Around the Web
Join the Newsmax Community
Please review Community Guidelines before posting a comment.
>> Register to share your comments with the community.
>> Login if you are already a member.
blog comments powered by Disqus
 
Email:
Country
Zip Code:
Privacy: We never share your email.
 
Hot Topics
Follow Newsmax
Like us
on Facebook
Follow us
on Twitter
Add us
on Google Plus
Around the Web
Top Stories
You May Also Like

Female Bosses Prone to Depression: Study

Friday, 21 Nov 2014 23:11 PM

Being the boss at work seems to raise the odds for symptoms of depression among women, but not men, a new study finds.  . . .

Olive Oil Linked to Dramatic Heart Benefits

Friday, 21 Nov 2014 17:45 PM

Regular consumption of olive oil can drastically improve heart health - especially in people who have recently switched  . . .

Woman Dies After Metal Detector Causes Pacemaker to Malfunction

Friday, 21 Nov 2014 17:38 PM

An airport metal detector caused a woman's pacemaker to malfunction and kill her while she was traveling with her husban . . .

Most Commented

Newsmax, Moneynews, Newsmax Health, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc.

 
NEWSMAX.COM
America's News Page
©  Newsmax Media, Inc.
All Rights Reserved