Scientists Find Genetic Pathway to Fight Heart Attacks

Thursday, 19 Jun 2014 08:08 AM

 

Share:
  Comment  |
   Contact Us  |
  Print  
|  A   A  
  Copy Shortlink
Four rare mutations in a single gene reduce the risk of heart disease by 40 percent, a new study suggests.

The discovery could lead to the development of new drugs to fight heart disease, according to the researchers at the Broad Institute at Massachusetts General Hospital and colleagues.

They conducted genetic analyses of nearly 4,000 people and identified four mutations in the APOC3 gene that significantly lower levels of triglycerides, a type of fat in the blood, as well as the risk of coronary heart disease.

Editor's note: No. 1 Best-Seller: A Revolutionary Heart-Disease Cure

The APOC3 gene produces a protein that's believed to prevent the removal of triglycerides from the blood. The four mutations all decrease APOC3 activity.

The findings suggest that high triglyceride levels -- rather than low levels of "good" HDL cholesterol -- play a major role in heart disease, according to the authors of the study in the June 18 issue of the New England Journal of Medicine.

"The combination of our genetic results, together with recent clinical trials of drugs that raised HDL levels but failed to prevent heart disease, are turning decades of conventional wisdom on its head," senior author Dr. Sekar Kathiresan, a Broad Institute associate member and director of preventive cardiology at Massachusetts General Hospital, said in an institute news release.

"HDL and triglycerides are both correlated with heart attack, and have an inverse relationship with one another -- the lower the HDL, the higher the triglycerides. It has long been presumed that low HDL is the causal factor in heart disease, and triglycerides are along for the ride. But our genetic data indicate that the true causal factor may not be HDL after all, but triglycerides."

Based on these findings, another member of the research team said preventive measures might need revision.

"We predict that lowering triglycerides specifically through inhibition of APOC3 would have a beneficial effect by lowering disease risk," study senior co-author Dr. Alex Reiner, a research professor of epidemiology at the University of Washington's School of Public Health, said in the news release.

Drugs to lower triglyceride levels exist, but have not been shown to prevent heart disease. This may be because their effect on triglyceride levels is relatively modest compared to the much greater impact of the APOC3 mutations, the researchers said.
 
Special: Warning Signs of a 'Silent' Heart Attack


© HealthDay

Share:
  Comment  |
   Contact Us  |
  Print  
  Copy Shortlink
Around the Web
Join the Newsmax Community
Please review Community Guidelines before posting a comment.
>> Register to share your comments with the community.
>> Login if you are already a member.
blog comments powered by Disqus
 
Email:
Country
Zip Code:
Privacy: We never share your email.
 
Hot Topics
Follow Newsmax
Like us
on Facebook
Follow us
on Twitter
Add us
on Google Plus
Around the Web
Top Stories
You May Also Like

Selenium Found to Boost Cancer Treatment

Tuesday, 25 Nov 2014 16:50 PM

Selenium - naturally found in such foods as garlic and- may help in the fight against certain types of cancer, a new stu . . .

Football Players Suffer Brain Damage From Even Mild Impacts: Study

Tuesday, 25 Nov 2014 16:43 PM

Researchers using new, enhanced imaging can now identify brain damage that occurs in professional football players follo . . .

Healthy Gut Bacteria Prevent Metabolic Syndrome: Study

Tuesday, 25 Nov 2014 16:35 PM

Promoting healthy gut bacteria, also known as "microbiota," can help treat or prevent metabolic syndrome, a new study f . . .

Most Commented

Newsmax, Moneynews, Newsmax Health, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc.

 
NEWSMAX.COM
America's News Page
©  Newsmax Media, Inc.
All Rights Reserved