New Drug Reduces Heart Damage

Monday, 11 Mar 2013 12:26 PM

 

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A single dose of an experimental anti-inflammatory treatment reduces heart muscle damage during an angioplasty operation to open blocked arteries, a study found Sunday.
 
The antibody inclacumab, developed by Swiss lab Hoffmann-La Roche, significantly reduced levels of the standard molecular markers troponin I and CK-MB in patients, compared to those who took a placebo in a clinical trial.
 
Patients who received the inclacumab dose saw troponin I levels drop 22.4 percent more after 16 hours and 24.4 percent after more at 24 hours (p=0.05), compared with patients on a placebo.
 
CK-MB levels dropped 16.3 percent more after 16 hours and 17.4 percent more at 24 hours, compared with patients on placebo.
 
"It was exciting to see that a single administration of inclacumab would yield clinical benefit," said the study's lead investigator Jean-Claude Tardif, director of the Research Center at the Montreal Heart Institute.
 
The phase II trial examined 530 patients with a median age of 61 experiencing a type of heart attack called non-ST-elevation myocardial infarction or NSTEMI.
 
Patients were randomized to receive an infusion of inclacumab of 20 milligrams per kilogram, five milligrams per kilogram or a placebo one hour before angioplasty.
 
The researchers also found that 24 hours after angioplasty, 18.3 percent of patients on the placebo had CK-MB increases more than three times the upper limit of normal.
 
Many clinical trials define that threshold as the onset of a post-angioplasty heart attack.
But only 8.9 percent of patients who received the higher dose of inclacumab experienced those same CK-MB increases.
 
"If we're able to confirm these results in potential future studies, this drug could become part of the therapeutic armamentarium in modern cardiology," Tardif said in a statement.
"You could use this drug more widely, in all patients coming in with heart attacks, although that would require additional large studies."
 
More than a million coronary angioplasty procedures are performed in the United States each year, costing more than $10 billion.
 
Angioplasty can damage heart tissue, which can trigger a need for more procedures, poor outcomes and higher health care costs .
 
During angioplasty, surgeons insert a balloon catheter to mechanically widen narrowed or obstructed arteries.
 

© AFP 2014

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