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Prostate Cancer: Top Five Drugs That Work

Thursday, 21 Oct 2010 04:43 PM


Prostate cancer develops in the prostate gland of males, which is a part of the reproductive system. Generally, prostate cancers grow slowly, though they can develop rapidly in some cases. Prostrate cancer can even spread from the infected part to bones and lymph nodes in the body. The prostate cancer causes pain, problems during sexual intercourse, difficulty in urinating, and even erectile dysfunction.
Prostate cancer can develop due to many causes including genetic and dietary factors. The detection of the cancer can be by symptoms, biopsy, and physical examination. The most commonly used drugs for the treatment of prostate cancer are:
  1. Flutamide: The drug is used in combination with luteinizing hormone-releasing hormone (LHRH) agonists for managing locally confined metastatic prostate cancer. The drug regimen should start eight weeks before the initiation of radiation therapy and continue during it. Adverse affects of this drug include hypertension, drowsiness, confusion, depression, anxiety, nervousness, anorexia, anemia, leukopenia, thrombocytopenia, hepatitis, jaundice, irritation at the injection site, and edema.
  2. Goserelin Acetate: Goserelin acetate is an injectable synthetic drug used for the treatment of prostate cancer. The drug is a gonadotropin releasing hormone super-agonist (GnRH agonist), also known as a luteinizing hormone releasing hormone (LHRH) agonist used to decrease sex hormone production in the body. The prostate cancer cells depend on hormones for growing. Hence, reducing the hormones hinders the cancer cells from growing, thereby arresting prostate cancer growth.
  3. Leuprolide: In a fashion similar to any other hormone agonists, this drug is used for treating hormone dependent cancers like prostate or breast cancers. It can also be used to treat estrogen-dependent conditions such as endometriosis or uterine fibroids, precocious puberty, and to control ovarian stimulation. Research on the drug also suggested it to be effective against autism as mercury is believed to bind to testosterone, which can be lowered by reducing testosterone levels in the body through the drug.
  4. Nilandron (Nilutamide): This is an anti-androgen drug used to treat advanced prostate cancer stages. The drug blocks the androgen receptor and hence prevents its interaction with the testosterone hormone. Most cancers are hormone dependent for their growth and survival, and hence, controlling hormone levels is effective therapy to fight cancers. This drug is used in combination with surgical castration for prostate cancers.
  5. Abiraterone Acetate: It is a pregnenolone analog currently under investigation as a new promising drug in castration-resistant prostate cancer treatment. The drug is orally administered. It irreversibly inhibits a rate-limiting enzyme in the androgen biosynthesis, thus blockings the androgen synthesis in the glands. In this manner, it acts against hormone dependent cancer cells.
All these drugs should be taken under strict medical supervision.


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