Circadian Rhythm Sleep Disorder: Top Drugs that Work

Wednesday, 20 Oct 2010 11:18 AM

Share:
  Comment  |
   Contact Us  |
  Print  
|  A   A  
  Copy Shortlink
Circadian rhythm sleep disorder is associated with the body’s internal sleep-wake rhythms and the light-dark cycle. While patients may exhibit symptoms similar to those of sleep disorder insomnia, circadian rhythm sleep disorder occurs either in combination with insomnia or as an isolated condition with excessive sleepiness during the daytime. Excessive sleepiness needs treatment, though the body clock can sometimes be realigned by changing habits.

The top drugs for the treatment of circadian rhythm sleep disorder include:
 
Melatonin
Treatment for circadian rhythm sleep disorder includes drugs and medications that contain the hormone melatonin, approved by the FDA as a dietary supplement and available over-the-counter. Melatonin is a naturally occurring biological sleep-aid secreted by the pineal gland.
 
Using circadian rhythm sleep disorder medication is a little tricky as the chosen drug formulations must allow patients to resume their normal cycles of sleep upon the cessation of the drug without causing any withdrawal symptoms. Therefore, doctors and medical practitioners administer melatonin and ask patients to cut back on their caffeine intake as caffeine may prevent sound sleep.
 
Tasimelteon
Tasimelteon is a drug that acts as a short-term sleep aid that has proven beneficial for the treatment of circadian rhythm sleep disorder. It has successfully concluded Phase III trials.
 
Chronotherapy
Chronotherapy is seen as an aid that enhances the efficacy of the drugs employed in treating sleep-wake schedule disorder. Chronotherapy has been shown to progressively advance or delay overall sleep time by at least one to two hours per day, on average.
 
Benzodiazepines
Benzodiazepines are chemical agents that help in the treatment of circadian rhythm sleep disorder. Benzodiazepines are preferred by doctors over barbiturates because benzodiazepines are relatively less toxic and have a much higher clinical efficacy. Circadian rhythm sleep disorder medication based on benzodiazepine is rapid in its action and provides faster and quicker relief. There are two classes of benzodiazepine-based drugs: short-acting and long-acting drugs. Their usage depends on the kind of treatment required, based on the intensity of the sleep-wake schedule disorder.
 
Triazolam (Halcion)
It is one of the top benzodiazepines used in the treatment of insomnia and excessive sleepiness. It is a short-acting agent prescribed for its effectiveness in helping patients fall asleep. However, this drug is not suitable for people with more serious problems such as sleep maintenance disorders.
 
For patients who suffer from insomnia, an intermediate benzodiazepine like Estazolam (ProSom) or Quazepam is recommended. Long-acting chemical agents have a longer elimination half-life, which means the total time taken for their disintegration to half the uptake amount takes longer.
 
Combination therapy
Ongoing research is currently addressing the problems of residual daytime effects and rebound insomnia. Since most drugs have addictive potential, small quantities must be administered over a well-defined period of time to prevent habit formation.
 
Short-acting benzodiazepines are the preferred drug of choice for circadian rhythm sleep disorder and are often used in combination with behavioral therapy.
 
For patients afflicted with circadian rhythm sleep disorder and insomnia for years, long-acting medication may be required to help alleviate their symptoms.

© Newsmax. All rights reserved.

Share:
  Comment  |
   Contact Us  |
  Print  
  Copy Shortlink

PLEASE NOTE: All information presented on Newsmax.com is for informational purposes only. It is not specific medical advice for any individual. All answers to reader questions are provided for informational purposes only. All information presented on our websites should not be construed as medical consultation or instruction. You should take no action solely on the basis of this publication’s contents. Readers are advised to consult a health professional about any issue regarding their health and well-being. While the information found on our websites is believed to be sensible and accurate based on the author’s best judgment, readers who fail to seek counsel from appropriate health professionals assume risk of any potential ill effects. The opinions expressed in Newsmaxhealth.com and Newsmax.com do not necessarily reflect those of Newsmax Media. Please note that this advice is generic and not specific to any individual. You should consult with your doctor before undertaking any medical or nutritional course of action.

Keeping you up to speed on Lifestyle, health, and money-saving tips
 
 
Get me on Fast Features
Keeping you up to speed on Lifestyle, health, and money-saving tips
 
Follow Newsmax
You May Also Like

Newsmax, Moneynews, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, NewsmaxWorld, NewsmaxHealth, are trademarks of Newsmax Media, Inc.

 
NEWSMAX.COM
America's News Page
©  Newsmax Media, Inc.
All Rights Reserved