Scientists ID New Way to Starve Tumors

Monday, 22 Apr 2013 03:55 PM

 

  Comment  |
   Contact  |
  Print  
|  A   A  
  Copy Shortlink
Hundreds of potential targets for new cancer drugs that could starve tumors have been identified by scientists who analyzed gene expression data from 22 types of malignancies.
 
The study revealed a number of cancer-associated changes in the metabolism of cells. To support their uncontrolled growth, cancer cells need to reprogram and "supercharge" a cell's normal metabolism, the researchers explained.
 
Pinpointing these metabolic changes could prove important in efforts to develop drugs that interfere with cancer metabolism, according to the study, which was published online in the journal Nature Biotechnology.
 
"The importance of this new study is its scope," lead investigator Dennis Vitkup, an associate professor of biomedical informatics at Columbia University Medical Center, said in a center news release. "So far, people have focused mainly on a few genes involved in major metabolic processes. Our study provides a comprehensive, global view of diverse metabolic alterations at the level of gene expression."
 
One of the major findings was that cancer-induced changes in metabolism are significantly different in various types of tumors.
 
"Our study clearly demonstrates that there are no single and universal changes in cancer metabolism," study co-author Dr. Matthew Vander Heiden, an assistant professor at MIT, said in the news release. "That means that to understand transformation in cancer metabolism, researchers will need to consider how different tumor types adapt their metabolism to meet their specific needs."
 
Targeting metabolism may be a way to strike cancer at its roots, according to Vitkup.
 
"You can knock out one, but the cells will usually find another pathway to turn on proliferation. Targeting metabolism may be more powerful, because if you starve a cell of energy or materials, it has nowhere to go," he explained.


© HealthDay

  Comment  |
   Contact  |
  Print  
  Copy Shortlink
Around the Web
Join the Newsmax Community
Please review Community Guidelines before posting a comment.
>> Register to share your comments with the community.
>> Login if you are already a member.
blog comments powered by Disqus
 
Email:
Country
Zip Code:
Privacy: We never share your email.
 
Hot Topics
Follow Newsmax
Like us
on Facebook
Follow us
on Twitter
Add us
on Google Plus
Around the Web
Top Stories
You May Also Like

Smoking Falls to All-Time Low

Wednesday, 26 Nov 2014 12:11 PM

The percentage of Americans who are smokers has fallen to an all-time low, now representing just 17.8 percent of the pop . . .

Fat to Blame for Half Million Cancer Cases a Year: Researchers

Wednesday, 26 Nov 2014 08:13 AM

Some half a million cases of cancer a year are due to people being overweight or obese, and the problem is particularly  . . .

Selenium Found to Boost Cancer Treatment

Tuesday, 25 Nov 2014 16:50 PM

Selenium - naturally found in such foods as garlic and- may help in the fight against certain types of cancer, a new stu . . .

Most Commented

Newsmax, Moneynews, Newsmax Health, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc.

 
NEWSMAX.COM
America's News Page
©  Newsmax Media, Inc.
All Rights Reserved