Tags: Cancer | Scientists ID New Way to Starve Tumors

Scientists ID New Way to Starve Tumors

Monday, 22 Apr 2013 03:55 PM

 

Hundreds of potential targets for new cancer drugs that could starve tumors have been identified by scientists who analyzed gene expression data from 22 types of malignancies.
 
The study revealed a number of cancer-associated changes in the metabolism of cells. To support their uncontrolled growth, cancer cells need to reprogram and "supercharge" a cell's normal metabolism, the researchers explained.
 
Pinpointing these metabolic changes could prove important in efforts to develop drugs that interfere with cancer metabolism, according to the study, which was published online in the journal Nature Biotechnology.
 
"The importance of this new study is its scope," lead investigator Dennis Vitkup, an associate professor of biomedical informatics at Columbia University Medical Center, said in a center news release. "So far, people have focused mainly on a few genes involved in major metabolic processes. Our study provides a comprehensive, global view of diverse metabolic alterations at the level of gene expression."
 
One of the major findings was that cancer-induced changes in metabolism are significantly different in various types of tumors.
 
"Our study clearly demonstrates that there are no single and universal changes in cancer metabolism," study co-author Dr. Matthew Vander Heiden, an assistant professor at MIT, said in the news release. "That means that to understand transformation in cancer metabolism, researchers will need to consider how different tumor types adapt their metabolism to meet their specific needs."
 
Targeting metabolism may be a way to strike cancer at its roots, according to Vitkup.
 
"You can knock out one, but the cells will usually find another pathway to turn on proliferation. Targeting metabolism may be more powerful, because if you starve a cell of energy or materials, it has nowhere to go," he explained.


© HealthDay

Around the Web
Join the Newsmax Community
Please review Community Guidelines before posting a comment.
>> Register to share your comments with the community.
>> Login if you are already a member.
blog comments powered by Disqus
 
Email:
Country
Zip Code:
Privacy: We never share your email.
 
Hot Topics
Follow Newsmax
Like us
on Facebook
Follow us
on Twitter
Add us
on Google Plus
Around the Web
Top Stories
You May Also Like

NFL Partners With Cancer Group on Prostate Treatment

Friday, 30 Jan 2015 12:59 PM

A U.S. cancer organization has partnered with the NFL alumni association ahead of Sunday's Super Bowl XLIX to raise awar . . .

California Declares E-Cigarettes a Health Threat

Wednesday, 28 Jan 2015 16:44 PM

California health officials on Wednesday declared electronic cigarettes a health threat that should be strictly regulate . . .

Ovarian Cancer Discovery Offers Hope for Better Treatment

Wednesday, 28 Jan 2015 13:59 PM

A discovery that sheds light on how two genes interact to trigger ovarian cancer promises to lead to a new drug in the b . . .

Most Commented

Newsmax, Moneynews, Newsmax Health, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc.

 
NEWSMAX.COM
America's News Page
©  Newsmax Media, Inc.
All Rights Reserved